Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia 30912, USA.
J Neurosurg. 2010 Feb;112(2):268-72. doi: 10.3171/2008.9.17689.
Patients undergoing craniotomies have traditionally received opiates with acetaminophen for the management of their postoperative pain. The use of narcotic pain medications can be costly, decrease rates of early postoperative ambulation, lengthen hospital stays, and alter a patient's neurological examination. The use of alternative pain medications such as tramadol may benefit patients by resolving many of these issues.
The authors conducted a randomized, blinded prospective study to evaluate the efficacy of alternative pain management strategies for patients following craniotomies. Fifty patients were randomly assigned either to a control group who received narcotics and acetaminophen alone or an experimental group who received tramadol in addition to narcotic pain medications (25 patients assigned to each group).
The control group was noted to have statistically significant higher visual analog scale pain scores, an increased length of hospital stay, and increased narcotic use compared with the tramadol group. The narcotics and acetaminophen group also had increased hospitalization costs when compared with the tramadol group.
The use of scheduled atypical analgesics such as tramadol in addition to narcotics with acetaminophen for the management of postoperative pain after craniotomy may provide better pain control, decrease the side effects associated with narcotic pain medications, encourage earlier postoperative ambulation, and reduce total hospitalization costs.
接受开颅手术的患者传统上接受含有对乙酰氨基酚的阿片类药物来缓解术后疼痛。使用麻醉性止痛药可能会增加成本、降低术后早期活动率、延长住院时间并改变患者的神经检查结果。使用曲马多等替代止痛药可能会通过解决这些问题使患者受益。
作者进行了一项随机、双盲前瞻性研究,以评估开颅术后替代疼痛管理策略对患者的疗效。50 名患者被随机分配到对照组(接受单独的阿片类药物和对乙酰氨基酚)或实验组(接受曲马多加阿片类药物)(每组 25 名患者)。
与曲马多组相比,对照组的视觉模拟评分疼痛明显更高,住院时间延长,阿片类药物用量增加。与曲马多组相比,阿片类药物和对乙酰氨基酚组的住院费用也增加了。
在开颅术后,除了使用含有对乙酰氨基酚的阿片类药物外,还使用曲马多等定时使用的非典型镇痛药来管理术后疼痛,可以更好地控制疼痛,减少与阿片类药物相关的副作用,鼓励术后早期活动,并降低总住院费用。