Sawaddiruk Passakorn, Paiboonworachat Sahattaya, Janthawichai Kittichai
Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Med Assoc Thai. 2010 Jul;93(7):812-7.
To compare the efficacy and effectiveness between ULTRACE, a new analgesic combination of tramadol/ acetaminophen, and tramadol/acetaminophen for acute postoperative pain after upper extremity surgery.
A double blind randomized controlled trial.
One hundred and eighty patients who underwent upper extremity surgery under brachial plexus block were randomized to receive either ULTRACE (n = 87) or tramadol and acetaminophen (n = 93) immediately after surgery in the postanesthetic care unit (PACU). Total morphine requirement, pain score (VRS) and drug adverse effects were compared between those two groups using independent single t-test, Mann-Whitney U-test, Chi-square test and Fisher-exact test respectively.
Total morphine requirement was significantly lower in subjects who used ULTRACE when compared with the tramadol and acetaminophen group (0.51 and 0.69 mg in the first 6 hours after the operation, 0.0 and 0.13 mg in hours 6-12 after the operation). Moreover there were fewer side effects in this ULTRACE group too.
ULTRACET has more efficacy and fewer side effects when compared with tramadol and acetaminophen in acute postoperative pain surgery.
比较曲马多/对乙酰氨基酚新型镇痛组合ULTRACE与曲马多/对乙酰氨基酚用于上肢手术后急性疼痛的疗效和有效性。
双盲随机对照试验。
180例在臂丛神经阻滞下接受上肢手术的患者在麻醉后护理单元（PACU）手术后立即随机接受ULTRACE（n = 87）或曲马多和对乙酰氨基酚（n = 93）治疗。分别使用独立单样本t检验、曼-惠特尼U检验、卡方检验和费舍尔精确检验比较两组患者的吗啡总需求量、疼痛评分（VRS）和药物不良反应。
与曲马多和对乙酰氨基酚组相比，使用ULTRACE的患者吗啡总需求量显著更低（术后前6小时分别为0.51和0.69毫克，术后6 - 12小时分别为0.0和0.13毫克）。此外，ULTRACE组的副作用也更少。
在急性术后疼痛手术中，与曲马多和对乙酰氨基酚相比，ULTRACET具有更高的疗效和更少的副作用。
