Jaenisch R
Whitehead Institute and Department of Biology, MIT 9 Cambridge Center, Cambridge, MA 02142, USA.
J Thromb Haemost. 2009 Jul;7 Suppl 1:21-3. doi: 10.1111/j.1538-7836.2009.03418.x.
Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most recently by introducing defined transcription factors into somatic cells. Nuclear reprogramming is of great medical interest as it has the potential to generate a source of patient-specific cells. This short review summarizes strategies to reprogram somatic cells to a pluripotent embryonic state and discuss the implications of this technology for transplantation medicine.
通过将体细胞核移植到去核卵母细胞中，以及最近通过向体细胞中导入特定转录因子，已实现将体细胞重编程为多能胚胎干细胞样状态。核重编程具有极大的医学价值，因为它有可能产生患者特异性细胞来源。这篇简短综述总结了将体细胞重编程为多能胚胎状态的策略，并讨论了该技术对移植医学的影响。
