Gevorkian E S, Tadevosian Iu V
Biokhimiia. 1990 Aug;55(8):1381-6.
The in vivo effect of estradiol on phosphoinositide catabolism initiation provoked by K(+)-depolarization of rat brain synaptosomal membranes was studied. The decreased yield of diacylglyceride was revealed on the 5th sec of initiation. It was found that estradiol markedly increases the phospholipid content, particularly that of phosphatidylinositol, in synaptosomal membranes but causes a simultaneous decrease of the neutral lipid content. The activity of phosphatidylinositol-specific phospholipase C is significantly decreased thereby. It was concluded that the effect of the steroid hormone on the genome provides for a functional status of membrane structures which slightly impedes the processes mediated by phosphoinositides.
研究了雌二醇对大鼠脑突触体膜K⁺去极化引发的磷酸肌醇分解代谢起始的体内效应。在起始的第5秒时发现二酰基甘油的产量降低。结果发现，雌二醇显著增加突触体膜中的磷脂含量，尤其是磷脂酰肌醇的含量，但同时导致中性脂质含量降低。磷脂酰肌醇特异性磷脂酶C的活性因此显著降低。得出的结论是，类固醇激素对基因组的作用为膜结构的功能状态提供了条件，该功能状态对由磷酸肌醇介导的过程有轻微阻碍。
