Gevorkian E S, Iavorian Zh V, Artsruni I G, Adopian N R
Vopr Med Khim. 1995 Sep-Oct;41(5):35-7.
The in vivo action of estradiol was shown to cause changes both in the total amount of phosphoinsitides and their individual fractions of rat synaptosomes. The maximum elevated levels of phosphoinositides was revealed on 1-hour exposure to the hormone. It is suggested the redistribution of phosphoinositides at the primary stage (1 hour postinjection) of exposure may rely on the initiation and functioning of the phosphoinositide mechanism, the ratio of triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of synaptosomal membranes for the functioning of this regulatory system.
已表明雌二醇的体内作用会导致大鼠突触体中磷酸肌醇的总量及其各个组分发生变化。在接触该激素1小时后，发现磷酸肌醇的水平升高到最大值。有人提出，在接触的初级阶段（注射后1小时）磷酸肌醇的重新分布可能依赖于磷酸肌醇机制的启动和运作，三磷酸肌醇与单磷酸肌醇的比例可能是该调节系统运作时突触体膜状态的一个特殊指标。
