School of Population Health, University of Queensland, Brisbane, QLD, Australia.
Br J Nutr. 2009 Dec;102(11):1668-77. doi: 10.1017/S000711450999081X. Epub 2009 Jul 27.
Several components of the metabolic syndrome, particularly diabetes and CVD, are known to be oxidative stress-related conditions and there is research to suggest that antioxidant nutrients may play a protective role in these conditions. Carotenoids are compounds derived primarily from plants and several have been shown to be potent antioxidant nutrients. The aim of the present study was to examine the associations between metabolic syndrome status and major serum carotenoids in adult Australians. Data on the presence of the metabolic syndrome, based on International Diabetes Federation 2005 criteria, were collected from 1523 adults aged 25 years and over in six randomly selected urban centres in Queensland, Australia, using a cross-sectional study design. Weight, height, BMI, waist circumference, blood pressure, fasting and 2 h blood glucose and lipids were determined, as well as five serum carotenoids. Mean serum alpha-, beta-carotenes and the sum of the five carotenoid concentrations were significantly lower (P < 0.05) in persons with the metabolic syndrome (after adjusting for age, sex, education, BMI status, alcohol intake, smoking, physical activity status and vitamin/mineral use) than persons without the syndrome. alpha-, beta- and total carotenoids also decreased significantly (P < 0.05) with increased number of components of the metabolic syndrome, after adjusting for these confounders. These differences were significant among former smokers and non-smokers, but not in present smokers. Low concentrations of serum alpha-, beta-carotenes and the sum of five carotenoids appear to be associated with metabolic syndrome status. Additional research, particularly longitudinal studies, may help to determine whether these associations are causally related to the metabolic syndrome, or are a result of the pathologies of the syndrome.
几种代谢综合征的组成部分，尤其是糖尿病和心血管疾病，都与氧化应激有关，有研究表明抗氧化营养素可能对这些疾病起到保护作用。类胡萝卜素主要来源于植物，有几种已被证明是有效的抗氧化营养素。本研究旨在检测澳大利亚成年人代谢综合征状态与主要血清类胡萝卜素之间的关系。采用横断面研究设计，在澳大利亚昆士兰州六个随机选定的城市中心，收集了 1523 名年龄在 25 岁及以上的成年人的代谢综合征（基于国际糖尿病联合会 2005 年标准）存在的数据。测定体重、身高、BMI、腰围、血压、空腹和 2 小时血糖和血脂，以及 5 种血清类胡萝卜素。代谢综合征患者的血清α-、β-胡萝卜素和 5 种类胡萝卜素浓度之和明显较低（P < 0.05）（在调整年龄、性别、教育程度、BMI 状态、酒精摄入量、吸烟、身体活动状况和维生素/矿物质使用情况后）。在调整了这些混杂因素后，随着代谢综合征成分数量的增加，α-、β-和总类胡萝卜素也明显下降（P < 0.05）。这些差异在曾经吸烟者和非吸烟者中是显著的，但在当前吸烟者中则不显著。血清α-、β-胡萝卜素和 5 种类胡萝卜素浓度较低似乎与代谢综合征状态有关。需要进一步的研究，特别是纵向研究，以确定这些关联是否与代谢综合征有因果关系，还是代谢综合征病理的结果。
