Sugiura Minoru, Nakamura Mieko, Ogawa Kazunori, Ikoma Yoshinori, Matsumoto Hikaru, Ando Fujiko, Shimokata Hiroshi, Yano Masamichi
Research Team for Health Benefit of Fruit, National Institute of Fruit Tree Science, 485-6 Okitsunaka-cho, Shimizu, Shizuoka 424-0292, Japan.
Br J Nutr. 2008 Dec;100(6):1297-306. doi: 10.1017/S0007114508978302. Epub 2008 Apr 29.
Recent epidemiological studies show the associations of serum antioxidant status with the metabolic syndrome. Oxidative stress may play an important role in the pathogenesis of diabetes and CVD. Actually, smoking is a potent oxidative stressor in man, but little is known about the interaction of serum carotenoids and the metabolic syndrome with smoking status. In this study, the associations of the serum carotenoids with the metabolic syndrome stratified by smoking habit were evaluated cross-sectionally. A total of 1073 subjects (357 male and 716 female) who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the study. Among total subjects, the OR for the metabolic syndrome in the highest tertile of serum beta-carotene was 0.41 (95 % CI 0.18, 0.92) after adjusting confounders. In current smokers, significantly lower OR were observed in the middle (OR 0.10; 95 % CI 0.01, 0.72) and highest (OR 0.06; 95 % CI 0.01, 0.73) tertiles of serum beta-carotene. Furthermore, lower OR were observed in accordance with tertiles of serum alpha-carotene and beta-cryptoxanthin in current smokers (P for trend 0.042 and 0.036, respectively). In contrast, in non-smokers, a significantly lower OR was observed in the highest tertile of serum beta-carotene (OR 0.30; 95 % CI 0.10, 0.89) after multiple adjustment. Inverse associations of serum carotenoids with the metabolic syndrome were more evident among current smokers than non-smokers. These results support that antioxidant carotenoids may have a protective effect against development of the metabolic syndrome, especially in current smokers who are exposed to a potent oxidative stress.
近期的流行病学研究表明血清抗氧化状态与代谢综合征之间存在关联。氧化应激可能在糖尿病和心血管疾病（CVD）的发病机制中起重要作用。实际上，吸烟是人类中一种强大的氧化应激源，但关于血清类胡萝卜素与代谢综合征和吸烟状态之间的相互作用却知之甚少。在本研究中，对按吸烟习惯分层的血清类胡萝卜素与代谢综合征之间的关联进行了横断面评估。共有1073名受试者（357名男性和716名女性）参与了该研究，他们在日本静冈县御殿场镇接受了健康检查。在全部受试者中，调整混杂因素后，血清β-胡萝卜素最高三分位数组中代谢综合征的比值比（OR）为0.41（95%置信区间[CI]为0.18，0.92）。在当前吸烟者中，血清β-胡萝卜素的中间（OR 0.10；95% CI 0.01，0.72）和最高（OR 0.06；95% CI 0.01，0.73）三分位数组中观察到显著较低的OR。此外，在当前吸烟者中，随着血清α-胡萝卜素和β-隐黄质三分位数的升高，OR也较低（趋势P值分别为0.042和0.036）。相比之下，在非吸烟者中，经过多重调整后，血清β-胡萝卜素最高三分位数组中观察到显著较低的OR（OR 0.30；95% CI 0.10，0.89）。血清类胡萝卜素与代谢综合征之间的负相关在当前吸烟者中比非吸烟者中更为明显。这些结果支持抗氧化类胡萝卜素可能对代谢综合征的发生具有保护作用，尤其是在暴露于强大氧化应激的当前吸烟者中。
