Secreto Frank J, Hoeppner Luke H, Westendorf Jennifer J
Departments of Orthopedic Surgery and Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Curr Osteoporos Rep. 2009 Jul;7(2):64-9. doi: 10.1007/s11914-009-0012-5.
Bone is one of the few tissues in the body with the capacity to regenerate and repair itself. Fractures usually are completely repaired in a relatively short time, but in a small percentage of cases, healing never occurs and nonunion is the result. Fracture repair and bone regeneration require the localized reactivation of signaling cascades that are crucial for skeletal development. The Wnt/beta-catenin signaling pathway is one such developmental pathway whose role in bone formation and regeneration recently has been appreciated. During the past decade, much has been learned about how Wnt pathways regulate bone mass. Small molecules and biologics aimed at this pathway are now being tested as potential new anabolic agents. This article reviews recent data demonstrating that Wnt pathways are active during fracture repair and that increasing the activities of Wnt pathway components accelerates bone regeneration.
骨骼是人体中少数具有自我再生和修复能力的组织之一。骨折通常在相对较短的时间内完全愈合，但在少数情况下，愈合过程无法发生，最终导致骨不连。骨折修复和骨再生需要局部重新激活对骨骼发育至关重要的信号级联反应。Wnt/β-连环蛋白信号通路就是这样一种发育途径，其在骨形成和再生中的作用最近才受到关注。在过去十年中，人们对Wnt通路如何调节骨量有了很多了解。针对该通路的小分子和生物制剂目前正在作为潜在的新型促合成代谢药物进行测试。本文综述了近期数据，这些数据表明Wnt通路在骨折修复过程中是活跃的，并且增加Wnt通路成分的活性可加速骨再生。
