Johnson Joey P, Ahn Jaimo, Dirschl Douglas R, Wixted John J, Evans Andrew R
Department of Orthopedic Surgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI.
OTA Int. 2023 May 4;6(2 Suppl):e262. doi: 10.1097/OI9.0000000000000262. eCollection 2023 May.
Orthopaedics as a field and a profession is fundamentally concerned with the treatment of musculoskeletal disease, in all of its many forms. Our collective understanding of the cellular mechanisms underlying musculoskeletal pathology resulting from injury continues to evolve, opening novel opportunities to develop orthobiologic treatments to improve care. It is a long path to move from an understanding of cellular pathology to development of successful clinical treatment, and this article proposes to discuss some of the challenges to achieving translational therapies in orthopaedics. The article will focus on challenges that clinicians will likely face in seeking to bring promising treatments forward to clinical practice and strategies for improving success in translational efforts.
骨科作为一个领域和专业，从根本上关注各种形式的肌肉骨骼疾病的治疗。我们对损伤导致的肌肉骨骼病理学潜在细胞机制的集体理解不断发展，为开发改善治疗的骨科生物治疗方法带来了新的机遇。从对细胞病理学的理解到成功的临床治疗开发是一条漫长的道路，本文旨在讨论骨科实现转化治疗面临的一些挑战。本文将重点关注临床医生在将有前景的治疗方法推向临床实践时可能面临的挑战，以及提高转化努力成功率的策略。
