Eckstein Felix, Guermazi Ali, Roemer Frank W
Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Strubergasse 21, A5020 Salzburg, Austria.
Radiol Clin North Am. 2009 Jul;47(4):655-73. doi: 10.1016/j.rcl.2009.03.002.
Whereas the strength of scoring systems in osteoarthritis (OA) lies in detecting local changes, involving small parts of the structures of interest (ie, cartilage lesions), quantitative measures are powerful where minute changes occur homogeneously throughout large structures. Cartilage measurements at 1.5 or 3 Tesla are technically accurate, reproducible, and sensitive to change. The rate of change in knee OA was found to be 1% to 2% annually. Risk factors of cartilage loss include a high BMI, meniscal pathology, malalignment, advanced radiographic OA, bone marrow alterations, and focal cartilage lesions. MRI of articular tissues represents a potent tool in experimental, epidemiological and pharmacological intervention studies; however, it is only with the availability of disease modifying drugs that it will play a relevant role in clinical practice.
骨关节炎（OA）评分系统的优势在于检测局部变化，涉及感兴趣结构的小部分（即软骨损伤），而定量测量在整个大结构中均匀发生微小变化时则很强大。1.5或3特斯拉下的软骨测量在技术上准确、可重复且对变化敏感。发现膝关节OA的变化率为每年1%至2%。软骨丢失的危险因素包括高体重指数、半月板病变、排列不齐、晚期放射学OA、骨髓改变和局灶性软骨损伤。关节组织的MRI是实验、流行病学和药物干预研究中的有力工具；然而，只有在有疾病修饰药物的情况下，它才会在临床实践中发挥相关作用。
