Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building 3rd Floor, Boston, MA 02118, USA.
Nat Rev Rheumatol. 2013 Apr;9(4):236-51. doi: 10.1038/nrrheum.2012.223. Epub 2013 Jan 15.
The use of MRI techniques to investigate tissue pathology has become increasingly widespread in osteoarthritis (OA) research. Semiquantitative assessment of the joints by expert interpreters of MRI data is a powerful tool that can increase our understanding of the natural history of this complex disease. Several reliable and validated semiquantitative scoring systems now exist and have been applied to large-scale, multicentre, cross-sectional and longitudinal observational epidemiological studies. Such approaches have advanced our understanding of the associations of different tissue pathologies with pain and improved the definition of joint alterations that lead to disease progression. Semiquantitative MRI outcome measures have also been applied in several clinical trials in OA. Indeed, interest in MRI-based semiquantitative scoring systems has led to the development of several novel scoring systems that can be applied to different joints: a knee synovitis scoring system based on contrast-enhanced MRI; the MRI Osteoarthritis Knee Score (MOAKS); the Hip Osteoarthritis MRI Score (HOAMS); and the Oslo Hand Osteoarthritis MRI score (OHOA-MRI). Although these new scoring systems offer theoretical advantages over pre-existing systems, whether they offer actual superiority with regard to reliability, responsiveness and validity remains to be seen.
磁共振成像（MRI）技术在骨关节炎（OA）研究中用于研究组织病理学的应用已经越来越广泛。MRI 数据的专家解读的半定量评估是一种强大的工具，可以帮助我们更好地了解这种复杂疾病的自然史。目前已经存在一些可靠且经过验证的半定量评分系统，并已应用于大规模、多中心、横断面和纵向观察性流行病学研究。这些方法使我们对不同组织病理学与疼痛之间的关联有了更深入的了解，并改善了导致疾病进展的关节改变的定义。半定量 MRI 结局测量也已应用于 OA 的几项临床试验中。事实上，对半定量 MRI 评分系统的兴趣促使了几种新的评分系统的开发，这些评分系统可应用于不同的关节：基于对比增强 MRI 的膝关节滑膜炎评分系统；MRI 骨关节炎膝关节评分（MOAKS）；髋关节骨关节炎 MRI 评分（HOAMS）；以及奥斯陆手骨关节炎 MRI 评分（OHOA-MRI）。虽然这些新的评分系统相对于现有的系统具有理论上的优势，但它们在可靠性、反应性和有效性方面是否具有实际优势仍有待观察。
