von Haehling Stephan, Schefold Joerg C, Lainscak Mitja, Doehner Wolfram, Anker Stefan D
Department of Cardiology, Applied Cachexia Research, Charité Medical School, Berlin, Germany.
Heart Fail Clin. 2009 Oct;5(4):549-60. doi: 10.1016/j.hfc.2009.04.001.
Chronic heart failure is viewed as a state of chronic inflammation. Many inflammatory markers have been shown to be up-regulated in patients who have this condition, but the markers' roles in clinical decision making have not yet been fully elucidated. A panel of biomarkers is likely to have a strong impact on patient management. Inflammatory biomarkers are interesting candidates that could answer specific clinical questions on their own or complement a multi-marker approach. This article provides a broad overview of several inflammatory biomarkers, including the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, IL-1, IL-18, and the soluble receptors TNFR-1, TNFR-2, IL-6R, and gp130. In addition to these acute phase reactants, several adhesion molecules, and lipopolysaccharide-signaling pathways are discussed.
慢性心力衰竭被视为一种慢性炎症状态。许多炎症标志物在患有这种疾病的患者中已被证明上调，但这些标志物在临床决策中的作用尚未完全阐明。一组生物标志物可能会对患者管理产生重大影响。炎症生物标志物是有趣的候选物，它们可以单独回答特定的临床问题或补充多标志物方法。本文广泛概述了几种炎症生物标志物，包括促炎细胞因子肿瘤坏死因子-α、白细胞介素（IL）-6、IL-1、IL-18，以及可溶性受体TNFR-1、TNFR-2、IL-6R和gp130。除了这些急性期反应物外，还讨论了几种黏附分子和脂多糖信号通路。
