Zannad Faiez, Pitt Bertram
Hôpital Jeanne d'Arc, Dommartin-les-Toul, France.
Heart Fail Clin. 2009 Oct;5(4):589-99. doi: 10.1016/j.hfc.2009.04.010.
The extracellular cardiac matrix (ECCM) plays an important role in the support of myocytes and fibroblasts. ECCM turnover is influenced by ischemia, stretch, inflammation, and neurohormonal mediators. Myocardial fibrosis is the consequence of several pathologic processes mediated by mechanical, neurohormonal, and cytokine factors. It is a major determinant of diastolic dysfunction and pumping capacity and may result in tissue heterogeneity, dys-synchrony, and arrhythmias. The measurement of various serum peptides arising from the metabolism of collagen types 1 and 3, of degradation fragments, and of specific metalloproteinases may provide noninvasive assessment of fibrosis. ECCM biomarkers are clinically useful tools, particularly given the potential for cardioprotective and cardioreparative pharmacologic strategies.
细胞外心脏基质（ECCM）在支持心肌细胞和成纤维细胞方面发挥着重要作用。ECCM的更新受缺血、牵张、炎症和神经激素介质的影响。心肌纤维化是由机械、神经激素和细胞因子介导的几种病理过程的结果。它是舒张功能障碍和泵血能力的主要决定因素，可能导致组织异质性、不同步和心律失常。对源自1型和3型胶原蛋白代谢、降解片段以及特定金属蛋白酶的各种血清肽的测量，可能提供纤维化的无创评估。ECCM生物标志物是临床上有用的工具，特别是考虑到心脏保护和心脏修复药物策略的潜力。
