Int J Cardiol. 2010 Nov 5;145(1):133-5. doi: 10.1016/j.ijcard.2009.06.060. Epub 2009 Jul 24.
In animal studies, the amplitude of the first heart sound (S1) is proportional to the rate of left ventricular pressure rise (LV dP/dt). To develop a clinical application for this property, we performed phono-electrocardiographic recordings using a digital hand-held device followed by an echocardiogram within 2 hours of a clinically indicated cardiac catheterization. Compared with the group with reduced dP/dt (<1000 mm Hg/s) or ejection fraction (EF) (<55%), the median S1/S2 detected at the cardiac base was higher in those with normal dP/dt or EF. On ROC analysis, S1/S2 significantly discriminated normal from reduced dP/dt and EF. This study demonstrated that S1, corrected for S2, is decreased in patients with impaired LV systolic function. Digital phonocardiography appears promising as an adjunctive bedside tool for evaluating left ventricular systolic function.
在动物研究中，第一心音（S1）的幅度与左心室压力上升率（LV dP/dt）成正比。为了将这一特性应用于临床，我们在临床指示的心导管检查后 2 小时内使用数字手持式设备进行声电图记录，并进行超声心动图检查。与 dP/dt（<1000mmHg/s）或射血分数（EF）（<55%）降低的组相比，在 dP/dt 或 EF 正常的组中，心底部检测到的 S1/S2 中位数更高。在 ROC 分析中，S1/S2 可显著区分正常和 dP/dt 及 EF 降低的情况。这项研究表明，S1 在左心室收缩功能受损的患者中降低，S2 校正后 S1 降低。数字心音图似乎有望成为评估左心室收缩功能的附加床边工具。
