Department of Oral and Maxillofacial Surgery, Wuhan University, Hubei, China.
Oral Oncol. 2009 Sep;45(9):752-9. doi: 10.1016/j.oraloncology.2009.01.016. Epub 2009 Jul 23.
Among the ameloblastomas, the desmoplastic variation is rare. The desmoplastic ameloblastoma (DA) is characterized by specific clinical, imaging, and histological features. The here presented retrospective analysis investigated the clinicoradiographic features of an overall of 115 DA-cases, having been reported in literature from 1984 to 2008. DA showed a nearly equal male to female ratio (55/59) with a prevalence within the forth and fifth decades. Sixty-two lesions occurred in the mandible and fifty-one lesions in the maxilla. Clinically, a painless swelling with buccal extension was the most common presentation being found in 48 cases. Radiologically, the lesion often presented multilocular (49.3%; 36/73), mixed radiolucent/radiopaque (55.6%; 50/90) and with ill-defined borders (64.0%; 48/75). Whereas enucleation provided a recurrence rate of 21.1%, resection reduced this rate remarkably to 3.1%. The average period until recurrence was 36.9 months. Histologically, scattered epithelial nests and extensively desmoplasia were prominent features of DA. In conclusion, these retrospective results confirm the statement that DA is a variation among ameloblastomas. DA present clinicoradiographic and histologic distinct features, when compared with "conventional ameloblastomas".
在造釉细胞瘤中，促结缔组织增生型是罕见的。促结缔组织增生型造釉细胞瘤（DA）的特征是具有特定的临床、影像学和组织学特征。这里回顾性分析了 1984 年至 2008 年文献中报道的总共 115 例 DA 病例的临床和影像学特征。DA 的男女比例几乎相等（55/59），高发于第四和第五个十年。62 例病变发生在下颌骨，51 例病变发生在上颌骨。临床上，最常见的表现是无痛性肿胀伴有颊侧扩展，有 48 例。影像学上，病变常呈多房性（49.3%；36/73）、混合性透亮/不透光（55.6%；50/90）和边界不清（64.0%；48/75）。虽然肿瘤剜除术的复发率为 21.1%，但切除术显著降低了这一比例，降至 3.1%。复发的平均时间为 36.9 个月。组织学上，散在的上皮巢和广泛的结缔组织增生是 DA 的显著特征。总之，这些回顾性结果证实了 DA 是造釉细胞瘤的一种变异的说法。DA 在临床表现、影像学和组织学上与“传统造釉细胞瘤”存在显著差异。
