Feigin Kristina, Bell Cynthia
Veterinary Dental Services, Boxborough, MA, United States.
Specialty Oral Pathology for Animals, Geneseo, IL, United States.
Front Vet Sci. 2024 Apr 4;11:1362237. doi: 10.3389/fvets.2024.1362237. eCollection 2024.
Ameloblastoma in dogs most often has a highly conserved acanthomatous cell morphology and is recognized as canine acanthomatous ameloblastoma (CAA) while conventional ameloblastoma (CA) makes up a smaller yet morphologically diverse group of epithelial odontogenic tumors. In humans, a rare desmoplastic histological subtype has distinctive clinical, radiological, and microscopic features. Desmoplastic ameloblastoma (DA) has not previously been described in dogs, although it has been rarely referenced in the veterinary literature. This is the first thorough description of a case series of DA in dogs and describes clinical presentation, diagnostic imaging findings, histopathological features for diagnosis, and treatment outcome. Clinically, DA most often presents as a mass or swelling in the rostral mandible or maxilla of middle age to older dogs. On diagnostic imaging, the lesion has a radiolucent or mixed pattern with well-defined borders and variable loculation. As a solid, fibrous tumor with obscured odontogenic epithelium, DA is challenging to diagnose histologically and can mimic several other oral tumors, both benign and malignant. As an ameloblastoma, the biological behavior of DA is locally destructive yet benign and prognosis is favorable following surgical excision.
犬成釉细胞瘤通常具有高度保守的棘皮瘤样细胞形态，被认为是犬棘皮瘤样成釉细胞瘤（CAA），而传统成釉细胞瘤（CA）则构成一组数量较少但形态多样的上皮性牙源性肿瘤。在人类中，一种罕见的促结缔组织增生性组织学亚型具有独特的临床、放射学和微观特征。促结缔组织增生性成釉细胞瘤（DA）此前在犬中尚未见报道，尽管在兽医文献中很少被提及。本文首次对犬DA病例系列进行了全面描述，并阐述了其临床表现、诊断性影像学检查结果、用于诊断的组织病理学特征以及治疗结果。临床上，DA最常表现为中年至老年犬的上颌前部或下颌前部出现肿块或肿胀。在诊断性影像学检查中，病变呈透射性或混合性影像，边界清晰，有不同程度的分叶。作为一种实性纤维性肿瘤，其牙源性上皮难以辨认，DA在组织学诊断上具有挑战性，并且可以模仿其他几种良性和恶性口腔肿瘤。作为成釉细胞瘤，DA的生物学行为具有局部破坏性，但为良性，手术切除后预后良好。
