Bartolini F, Gundersen G G
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Biochim Biophys Acta. 2010 Feb;1803(2):164-73. doi: 10.1016/j.bbamcr.2009.07.006. Epub 2009 Jul 23.
Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their regulation of MT stability independent of their activity on actin. Formins regulate MT stability alone or in combination with accessory MT binding proteins that have previously been implicated in the stabilization of MTs downstream of polarity cues. As actin and MT arrays are typically remodeled downstream of signaling pathways that orchestrate cell shape and division, formins are emerging as excellent candidates for coordinating the responses of the cytoskeletal in diverse regulated and homeostatic processes.
formin蛋白最近被认为是微管（MT）细胞骨架的重要调节因子，它们在间期和有丝分裂过程中调节特定微管的动力学。formin蛋白与微管细胞骨架的关联及其对微管动力学的作用是相对未被探索的领域，但越来越多的证据支持它们在调节微管稳定性方面的直接作用，这与其对肌动蛋白的活性无关。formin蛋白单独或与辅助性微管结合蛋白共同调节微管稳定性，这些辅助性微管结合蛋白先前被认为与极性信号下游微管的稳定有关。由于肌动蛋白和微管阵列通常在协调细胞形状和分裂的信号通路下游进行重塑，formin蛋白正成为在各种调节和稳态过程中协调细胞骨架反应的优秀候选者。
