Departamento de Química Geral e Inorgânica, Instituto de Química, UNESP, CEP, 14801-970 Araraquara, SP, Brazil.
Eur J Med Chem. 2009 Nov;44(11):4611-5. doi: 10.1016/j.ejmech.2009.06.032. Epub 2009 Jul 4.
The reactions between Pd(C(2),N-dmba)(micro-X) (dmba=N,N-dimethylbenzylamine; X=Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C(2),N-dmba)(Cl)(tu)] (1) and [Pd(C(2),N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), (1)H- and (13)C{(1)H} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined.
室温下，Pd(C(2),N-dmba)(micro-X)（dmba=N,N-二甲基苄胺；X=Cl、Br）与硫脲（tu）以 1:2 的摩尔比反应，得到单核化合物[Pd(C(2),N-dmba)(Cl)(tu)]（1）和[Pd(C(2),N-dmba)(Br)(tu)]（2），通过元素分析和红外（IR）、（1）H-和（13）C{(1)H} NMR 光谱对其进行了表征。通过单晶 X 射线衍射确定了 2 的晶体和分子结构。使用两种鼠肿瘤细胞系，即乳腺腺癌（LM3）和肺腺癌（LP07），对化合物 1、2、tu、dmba 和顺铂进行了体外细胞毒性测定。还对化合物 1、2、tu 和 dmba 进行了结核分枝杆菌的测试，并确定了它们的 MIC 值。
