Xu Chuantian, Zhu Qiyun, Yang Huanliang, Zhang Xiumei, Qiao Chuanling, Chen Yan, Xin Xiaoguang, Chen Hualan
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laborattory of Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
J Clin Virol. 2009 Oct;46(2):192-5. doi: 10.1016/j.jcv.2009.06.022. Epub 2009 Jul 25.
H1N2 is one of the main subtypes of influenza, which circulates in swine all over the world.
To investigate the prevalence and genetic of H1N2 in swine of China.
Two H1N2 swine influenza viruses were isolated from Tianjin and Guangdong province of China in 2004 and 2006, respectively. The molecular evolution of eight gene segments was analyzed.
A/Swine/Tianjin/1/2004 has low identity with A/Swine/Guangdong/2006; in the phylogenetic tree of PA gene, A/Swine/Guangdong/1/2006 and A/Swine/Guangxi/1/2006 along with the H1N2 swine isolates of North America formed a cluster; and A/Swine/Tianjin/2004 and A/Swine/Zhejiang/2004, along with the classical H1N1 swine isolates formed another cluster; except that NA gene of A/Swine/Tianjin/1/2004 fell into the cluster of the H3N2 human influenza virus, indicating the reassortment between H3N2 human and H1N1 swine influenza viruses.
Two different genotypes of H1N2 appeared among pigs in China. A/swine/Guangdong/1/06 was probably from H1N2 swine influenza viruses of North America; while A/swine/Tianjin/1/04 maybe come from reassortments of classical H1N1 swine and H3N2 human viruses prevalent in North America.
H1N2是流感的主要亚型之一，在全球猪群中传播。
调查中国猪群中H1N2的流行情况和基因特征。
2004年和2006年分别从中国天津和广东省分离出两株H1N2猪流感病毒。分析了八个基因片段的分子进化情况。
A/猪/天津/1/2004与A/猪/广东/2006的同源性较低；在PA基因的系统发育树中，A/猪/广东/1/2006和A/猪/广西/1/2006与北美H1N2猪分离株形成一个簇；A/猪/天津/2004和A/猪/浙江/2004与经典H1N1猪分离株形成另一个簇；除A/猪/天津/1/2004的NA基因落入H3N2人流感病毒簇外，表明H3N2人流感病毒与H1N1猪流感病毒之间发生了重配。
中国猪群中出现了两种不同基因型的H1N2。A/猪/广东/1/06可能来源于北美H1N2猪流感病毒；而A/猪/天津/1/04可能来自北美流行的经典H1N1猪病毒和H3N2人病毒的重配。
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