子宫内膜异位症的非人灵长类动物模型：研究及其对生育力的影响
The non-human primate model of endometriosis: research and implications for fecundity.
作者信息
Braundmeier A G, Fazleabas A T
机构信息
Department of Obstetrics and Gynecology (MC808), College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Mol Hum Reprod. 2009 Oct;15(10):577-86. doi: 10.1093/molehr/gap057. Epub 2009 Jul 24.
Abstract
The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).
摘要
子宫内膜异位症动物模型的建立对于研究疾病发病机制和治疗干预至关重要。这些模型将提高我们评估与该疾病相关的生育力低下原因的能力，并为治疗调节剂提供一线验证。目前已经开发了啮齿动物和非人类灵长类动物模型，但每种模型都有其局限性。本手稿的目的是总结目前关于子宫内膜异位症的发生、疾病进展以及使用狒狒（埃及狒狒）实验性诱导的子宫内膜异位症模型的治疗靶点有效性的研究结果和理论。
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