D'Hooghe T M, Bambra C S, Cornillie F J, Isahakia M, Koninckx P R
Department of Obstetrics and Gynecology, U.Z. Gasthuisberg K.U. Leuven, Belgium.
Biol Reprod. 1991 Sep;45(3):411-6. doi: 10.1095/biolreprod45.3.411.
The prevalence of spontaneous endometriosis was investigated by laparoscopy in 52 baboons (Papio anubis and Papio cynocephalus) of proven fertility. Clinical endometriosis was diagnosed in 9 (17%) and 4 (8%) baboons with or without a previous hysterotomy, respectively. Endometriosis was confirmed by histology in 75% of these animals. The 37 endometriotic lesions were classified as typical (13%), subtle (57%), or suspicious (30%); and the percentage of histological confirmation was 100%, 61%, and 50%, respectively. Lesions were found on the uterosacral ligaments and in Douglas' pouch (46%), on the uterine peritoneum and the uterovesical fold (38%), and on uterine-omental adhesions (11%). Only 5% of the lesions were localized on the ovarian ligament, whereas ovarian endometriosis was not found. This study for the first time demonstrates that spontaneous endometriosis occurs in healthy baboons with proven fertility. It also shows that the laparoscopic appearances, the histological aspect, and the localization of the pelvic lesions are comparable to those found in women. We therefore conclude that the baboon is a good animal model for the study of endometriosis.
通过腹腔镜检查对52只已证实具有生育能力的狒狒（阿拉伯狒狒和东非狒狒）的自发性子宫内膜异位症患病率进行了调查。分别在9只（17%）和4只（8%）有或没有既往子宫切开术的狒狒中诊断出临床子宫内膜异位症。其中75%的动物经组织学证实患有子宫内膜异位症。37个子宫内膜异位病变被分类为典型（13%）、细微（57%）或可疑（30%）；组织学确诊率分别为100%、61%和50%。病变发现于子宫骶韧带和Douglas窝（46%）、子宫腹膜和子宫膀胱反折处（38%）以及子宫网膜粘连处（11%）。只有5%的病变位于卵巢韧带，未发现卵巢子宫内膜异位症。这项研究首次证明，自发性子宫内膜异位症发生在已证实具有生育能力的健康狒狒身上。研究还表明，腹腔镜表现、组织学特征以及盆腔病变的定位与在女性中发现的情况相当。因此，我们得出结论，狒狒是研究子宫内膜异位症的良好动物模型。
