我们从动物模型中学到了什么以了解子宫内膜异位症相关不孕症的病因和病理。
What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility.
作者信息
Tan Zhouyurong, Hung Sze-Wan, Zheng Xu, Wang Chi-Chiu, Chung Jacqueline Pui-Wah, Zhang Tao
机构信息
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong.
Reproduction and Development, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
出版信息
Biomedicines. 2022 Jun 23;10(7):1483. doi: 10.3390/biomedicines10071483.
Endometrioma (OMA) is the most common subtype of endometriosis, in which the endometriotic lesions are implanted in the ovary. Women with OMA are usually associated with infertility, presenting with reduced ovarian reserve, low oocyte quantity and quality, and poor fertility outcomes. However, the underlying pathological mechanisms in OMA-related infertility are still unclear. Due to the limitations and ethical issues of human studies in reproduction, animal models that recapitulate OMA characteristics and its related infertility are critical for mechanistic studies and subsequent drug development, preclinical testing, and clinical trials. This review summarized the investigations of OMA-related infertility based on previous and latest endometrioma models, providing the possible pathogenesis and potential therapeutic targets for further studies.
卵巢子宫内膜异位囊肿（OMA）是子宫内膜异位症最常见的亚型，其中异位的子宫内膜病灶种植于卵巢。患有OMA的女性通常伴有不孕，表现为卵巢储备功能下降、卵母细胞数量和质量降低以及生育结局不佳。然而，OMA相关不孕的潜在病理机制仍不清楚。由于生殖领域人体研究存在局限性和伦理问题，能够重现OMA特征及其相关不孕情况的动物模型对于机制研究以及后续的药物研发、临床前测试和临床试验至关重要。本综述基于既往和最新的卵巢子宫内膜异位囊肿模型总结了OMA相关不孕的研究，为进一步研究提供了可能的发病机制和潜在治疗靶点。
Zotero 插件