Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey.
Clin Appl Thromb Hemost. 2010 Dec;16(6):637-42. doi: 10.1177/1076029609339747. Epub 2009 Jul 24.
This study was performed to investigate the platelet aggregation alterations in platelet-rich plasma (PRP) samples of children with Helicobacter pylori (H pylori) infection. Platelet aggregation induced by adenosine diphosphate (ADP), collagen, ristocetin, or epinephrine was studied with photometric aggregometry in 30 patients before and after eradication therapy and in a control group including 15 children. The pretreatment mean maximum aggregation values and slope were significantly lower (P < .0001) in the study group at 10 μmol/L concentrations of ADP (ADP-like defect). The maximum aggregation values and slope revealed no significant differences (P > 0.05) between the study group after therapy and the control group. We concluded that H pylori infection may cause dysfunction of platelets in children and can be reversed by H pylori eradication therapy. Further studies should be carried out to determine the mechanisms of platelet dysfunction in children with H pylori infection.
本研究旨在探讨富血小板血浆（PRP）样本中血小板聚集改变与儿童幽门螺杆菌（H pylori）感染的关系。使用光密度法对 30 例患儿进行了血小板聚集诱导实验，包括治疗前后的血小板聚集诱导剂二磷酸腺苷（ADP）、胶原、瑞斯托霉素和肾上腺素，同时也纳入了 15 名儿童作为对照组。研究组在 10 μmol/L 的 ADP 浓度下（ADP 样缺陷），预处理的最大聚集值和斜率明显较低（P <.0001）。治疗后研究组与对照组的最大聚集值和斜率无显著差异（P > 0.05）。我们得出结论，H pylori 感染可能导致儿童血小板功能障碍，而 H pylori 根除治疗可以逆转这种功能障碍。需要进一步的研究来确定 H pylori 感染儿童血小板功能障碍的机制。
