University of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Child Health and Diseases, Ankara, Turkey
University of Health Sciences Turkey, Gülhane Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey
J Clin Res Pediatr Endocrinol. 2023 Feb 27;15(1):55-61. doi: 10.4274/jcrpe.galenos.2022.2022-6-13. Epub 2022 Oct 20.
Premature adrenarche (PA) has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet (PLT) aggregation. Here, we evaluated the effects of PA on PLT aggregation in PLT-rich plasma samples from female patients.
The study included 40 female patients diagnosed with PA between February, 2014 and June, 2018 and 30 healthy female individuals as a control group. Adenosine diphosphate (ADP) and collagen-induced PLT aggregation were studied via the photometric aggregometry method.
There were no significant differences in the PLT count or volume values between those participants with PA and the control group. Additionally, the ADP-induced maximum aggregation time, value, and slope values did not significantly differ between the patient and control groups (p>0.05). However, the collagen-induced maximum aggregation time, value, and slope values were significantly higher in the studygroup (p<0.001).
Increased collagen-induced PLT aggregation was detected in female patients with PA. As PA is associated with a higher risk of cardiovascular events later in life, close follow-up of PA in this respect may be beneficial.
性早熟（PA）与肾上腺雄激素增加有关，已知这种高雄激素环境会导致血小板（PLT）聚集增加。在这里，我们评估了 PA 对来自女性患者富含 PLT 的血浆样本中 PLT 聚集的影响。
本研究纳入了 2014 年 2 月至 2018 年 6 月期间被诊断为 PA 的 40 名女性患者和 30 名健康女性作为对照组。通过比色聚集法研究了二磷酸腺苷（ADP）和胶原诱导的 PLT 聚集。
PA 组与对照组之间的 PLT 计数或体积值无显著差异。此外，患者组和对照组之间 ADP 诱导的最大聚集时间、值和斜率值无显著差异（p>0.05）。然而，胶原诱导的最大聚集时间、值和斜率值在研究组中显著升高（p<0.001）。
在患有 PA 的女性患者中检测到胶原诱导的 PLT 聚集增加。由于 PA 与日后发生心血管事件的风险增加有关，因此在这方面密切随访 PA 可能是有益的。
