Hu N
Zhonghua Yi Xue Za Zhi. 1990 Dec;70(12):679-81, 46.
Follow-up survey of 622 esophageal cancer (EC) positive families found during 1978-1979 was carried out in 1989 in a total of 5037 families. During this period (1978-1988), 35.8% of new EC deaths were found from 393 families with two or more EC deaths which accounted for only 7.8% (393/5037) of the total families. When the EC positive families were divided into three groups with 1, 2 and greater than or equal to 3 EC deaths in each, the EC deaths among offsprings of EC free parents were 6.7%, 11.1%, and 15.7% respectively. Offsprings from households with one parent died of EC belonging to family groups with 2 or greater than or equal to 3 EC deaths had different EC frequencies (9.5% versus 22.8%). In 184 families with greater than or equal to 3 EC deaths, offsprings from households with one or both parents died of EC showed also higher EC mortality (22.8% and 22.7% respectively) than those from households with EC free parents (15.7%). These results pointed to a strong tendency of familial aggregation of EC and the existence of genetically determined susceptibility to this human malignancy.
1989年对1978 - 1979年间发现的622个食管癌（EC）阳性家庭进行了随访调查，涉及总共5037个家庭。在此期间（1978 - 1988年），在393个有两例或更多例EC死亡的家庭中发现了35.8%的新EC死亡病例，而这些家庭仅占总家庭数的7.8%（393/5037）。当将EC阳性家庭分为每组有1例、2例和大于或等于3例EC死亡的三组时，无EC父母的后代中的EC死亡率分别为6.7%、11.1%和15.7%。来自父母一方死于EC且属于有2例或大于或等于3例EC死亡的家庭组的后代，其EC发生率不同（9.5%对22.8%）。在184个有大于或等于3例EC死亡的家庭中，父母一方或双方死于EC的家庭的后代也显示出比无EC父母的家庭更高的EC死亡率（分别为22.8%和22.7%对15.7%）。这些结果表明EC存在强烈的家族聚集倾向以及存在对这种人类恶性肿瘤的遗传易感性。
