Dawsey S M, Yu Y, Taylor P R, Li J Y, Shen Q, Shu Y J, Liu S F, Zhao H Z, Cao S G, Wang G Q
Cancer Prevention Studies Branch, National Cancer Institute, Bethesda, Maryland 20892.
Acta Cytol. 1994 Mar-Apr;38(2):183-92.
This paper reports a 15-year follow-up study of 12,693 persons in Linxian, China, who were originally screened by esophageal balloon cytology in 1974. The purpose of the study was to evaluate the ability of esophageal balloon cytology to identify individuals at increased risk for developing esophageal cancer. Age, sex and cytologic diagnoses were obtained from the original 1974 records, and information on vital status, cancer experience and potential confounding risk factors was collected from interviews and medical abstracts in 1989. A total of 1,162 incident cases of esophageal cancer and 993 deaths due to esophageal cancer were identified and used in this analysis. The follow-up study showed that the risk of esophageal cancer incidence and mortality increased in parallel with the presumed severity of the 1974 Chinese cytologic diagnoses. After adjusting for potential confounding factors, the relative risks (and 95% confidence intervals) for esophageal cancer incidence, by cytologic diagnosis, were: normal, 1.00; esophagitis, 1.52 (1.07-2.14); hyperplasia, 1.17 (1.02-1.33); dysplasia 1, 1.53 (1.10-2.14); dysplasia 2, 1.89 (1.47-2.41); and suspicious for cancer, 5.77 (3.79-8.80). These results suggest that esophageal balloon cytology, as performed and interpreted in Linxian in 1974, successfully identified individuals at increased risk for esophageal cancer.
本文报告了对中国林县12693人的一项为期15年的随访研究，这些人于1974年最初接受了食管气囊细胞学筛查。该研究的目的是评估食管气囊细胞学识别食管癌发病风险增加个体的能力。年龄、性别和细胞学诊断信息来自1974年的原始记录，关于生命状态、癌症经历和潜在混杂风险因素的信息于1989年通过访谈和医学摘要收集。本分析共纳入了1162例食管癌发病病例和993例食管癌死亡病例。随访研究表明，食管癌发病和死亡风险与1974年中国细胞学诊断的假定严重程度平行增加。在对潜在混杂因素进行调整后，按细胞学诊断划分的食管癌发病相对风险（及95%置信区间）为：正常，1.00；食管炎，1.52（1.07 - 2.14）；增生，1.17（1.02 - 1.33）；发育异常1级，1.53（1.10 - 2.14）；发育异常2级，1.89（1.47 - 2.41）；癌症可疑，5.77（3.79 - 8.80）。这些结果表明，1974年在林县进行和解读的食管气囊细胞学成功识别出了食管癌发病风险增加的个体。
