Pascual A, López-López G, Aragón J, Perea E J
Department of Microbiology, School of Medicine, Seville, Spain.
Chemotherapy. 1990;36(6):422-7. doi: 10.1159/000238799.
The effect of three macrolides (azithromycin, roxithromycin and erythromycin) on the interaction in vitro of human polymorphonuclear leukocytes (PMNs) with Staphylococcus aureus was examined. The exposure of S. aureus to 0.25 MIC of roxithromycin and erythromycin but not of azithromycin significantly increased the uptake of opsonized bacteria by human PMNs. The preincubation of PMNs with 1, 10 and 25 mg/l of the three antimicrobial agents did not affect either the uptake of S. aureus or the superoxide radical production by human PMNs. At these same concentrations the three agents showed slight but not significant intracellular activity in PMNs against S. aureus. It is concluded that treatment of S. aureus with subinhibitory concentrations of roxithromycin and erythromycin enhanced phagocytosis by PMNs, but the three macrolides tested did not directly affect the functions of human PMNs against S. aureus.
研究了三种大环内酯类药物（阿奇霉素、罗红霉素和红霉素）对人多形核白细胞（PMN）与金黄色葡萄球菌体外相互作用的影响。金黄色葡萄球菌暴露于0.25倍最小抑菌浓度（MIC）的罗红霉素和红霉素，但不包括阿奇霉素，可显著增加人PMN对调理素化细菌的摄取。PMN与1、10和25mg/l的这三种抗菌药物预孵育，既不影响人PMN对金黄色葡萄球菌的摄取，也不影响其超氧阴离子的产生。在这些相同浓度下，这三种药物在PMN中对金黄色葡萄球菌显示出轻微但不显著的细胞内活性。得出的结论是，用亚抑菌浓度的罗红霉素和红霉素治疗金黄色葡萄球菌可增强PMN的吞噬作用，但所测试的三种大环内酯类药物并未直接影响人PMN对金黄色葡萄球菌的功能。
