Ligand-receptor and junction-mediated cell-cell interactions: comparison of the two principles.

Two major forms of cell-cell interaction--namely, ligand-receptor interactions and junction-mediated interactions--have different functional implications and naturally supplement each other in the most important tissue processes. The former type of interaction may be defined as distant and mainly "intertissue"; as a rule it determines temporal coordination of cell functioning. The latter is local and preferentially "intratissue"; it determines spatial coordination of cell activity.