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An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography.

作者信息

Prenen G H, Go K G, Zuiderveen F, Paans A M, Vaalburg W

机构信息

Department of Neurosurgery, University Hospital Groningen, The Netherlands.

出版信息

Int J Rad Appl Instrum A. 1990;41(12):1209-16. doi: 10.1016/0883-2889(90)90208-x.

DOI:10.1016/0883-2889(90)90208-x
PMID:1963420
Abstract

1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after injection into adult Wistar rats and cats was investigated by PET. When the tracer was injected into cats, 3 weeks after inflicting a unilateral freezing lesion upon the brain, accumulation of 1-11C-acetoacetic acid in the ipsilateral brain hemisphere was observed.

摘要

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