用于正电子发射断层扫描的碳-11标记脯氨酸的制备。在患有Walker 256癌肉瘤的大鼠中的初步分布研究。
The preparation of carbon-11 labelled proline for positron emission tomography. Preliminary distribution studies in rats with Walker 256 carcinosarcoma.
作者信息
Bolster J M, ten Hoeve W, Vaalburg W, van Dijk T H, Zijlstra J B, Paans A M, Wynberg H, Woldring M G
出版信息
Int J Appl Radiat Isot. 1985 May;36(5):339-43. doi: 10.1016/0020-708x(85)90272-8.
PMID:3874834
Abstract
DL-[1-11C]Proline has been synthesized by carboxylation of alpha-lithiopyrrolidyl-N-tert-butyl-formamidine with a radiochemical yield of up to 18% without correction for decay. The total synthesis time is 45 min. Accumulation of DL-[1-11C]proline has been shown in Walker 256 carcinosarcoma transplanted in rats. A tumor/non-tumor ratio of 5.9 was found at 45 min after i.v. injection.
摘要
DL-[1-¹¹C]脯氨酸是通过α-锂代吡咯烷基-N-叔丁基甲脒的羧化反应合成的，放射化学产率高达18%（未校正衰变）。总合成时间为45分钟。已证明DL-[1-¹¹C]脯氨酸在移植于大鼠体内的Walker 256癌肉瘤中有蓄积。静脉注射后45分钟时肿瘤/非肿瘤比值为5.9。
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