Shayeghi M, Nasirian H, Nourjah N, Baniardelan M, Shayeghi F, Aboulhassani M
Department of Medical Entomology and Vector Control, School of Public Health and Institute of Public Health Researches, Tehran University of Medical Sciences, P.O. Box 6446-14155, Tehran, Islamic Republic of Iran.
Pak J Biol Sci. 2009 May 1;12(9):696-701. doi: 10.3923/pjbs.2009.696.701.
In this study whole blood cholinesterase activities of the agriculture and hygiene spray workers exposed to organophosphorus and carbamate compounds from different parts of Tehran Province in Iran were determined. Lovi Bond method was used in three stages including prepare the questionnaires about spray worker body health conditions, taking their blood samples before and after working and their insight to insecticides and prepare the required solutions. Results showed that no any changes were observed in the 50% of the spray worker blood cholinesterase activity after working. In the 32.4% of them, cholinesterase activity has decreased up to extensive poisoning and in the 17.6% of them cholinesterase activity was much decreased at the end of an acute or severe poisoning, whereas in testifier workers less than 5.9% of them cholinesterase activity was decreased and in the 94.1% of testifier workers cholinesterase activity was normal. Analysis of the data demonstrated that no significant relationship between spray worker blood cholinesterase activity, age groups, history of working, knowledge, cigarette smoking, history of toxicity and their responsibilities were observed. The measurement of pre-exposure cholinesterase values is essential for comparison of the values after pesticide application.
在本研究中,测定了伊朗德黑兰省不同地区接触有机磷和氨基甲酸酯类化合物的农业和卫生喷雾工人的全血胆碱酯酶活性。采用洛维邦德法分三个阶段进行,包括编制喷雾工人身体健康状况问卷、采集其工作前后的血液样本以及他们对杀虫剂的了解情况并配制所需溶液。结果显示,50%的喷雾工人工作后血液胆碱酯酶活性未观察到任何变化。其中32.4%的人胆碱酯酶活性下降至重度中毒水平,17.6%的人在急性或重度中毒末期胆碱酯酶活性大幅下降,而在对照工人中,不到5.9%的人胆碱酯酶活性下降,94.1%的对照工人胆碱酯酶活性正常。数据分析表明,喷雾工人血液胆碱酯酶活性与年龄组、工作史、知识水平、吸烟情况、中毒史及其职责之间未观察到显著关系。暴露前胆碱酯酶值的测定对于比较施用农药后的数值至关重要。