Miller S, Shah M A
J Environ Sci Health B. 1982;17(2):125-42. doi: 10.1080/03601238209372307.
Five reference laboratories were established in Pakistan for monitoring cholinesterase (ChE) activities of workers exposed to organophosphorus compounds. ChE activities were determined by the Michel and tintometric method. Observations of ChE activities were made during two malaria seasons. The first season showed that although a significant depression of cholinesterase occurred among some of the workers, the ChE activities of workers were within the normal range during the following season. The reason for the difference is discussed. Similar studies were undertaken in Haiti. Mean and standard deviations (SD) were calculated for comparison of the tintometric versus the Michel method. The data show a correlation between the methods. For further evaluation of the tintometric method, organophosphorus and oxon analog inhibition of cholinesterase were determined in vitro. The tabulated data show that the tintometric method is adequate for determining whether a worker is exposed to dangerous amounts of insecticides.
巴基斯坦设立了五个参考实验室，用于监测接触有机磷化合物工人的胆碱酯酶（ChE）活性。胆碱酯酶活性通过米歇尔法和比色法测定。在两个疟疾季节对胆碱酯酶活性进行了观察。第一个季节显示，虽然一些工人的胆碱酯酶出现了显著下降，但在下个季节工人的胆碱酯酶活性仍在正常范围内。讨论了差异产生的原因。在海地开展了类似研究。计算了比色法和米歇尔法的均值及标准差（SD）以进行比较。数据显示两种方法之间存在相关性。为进一步评估比色法，在体外测定了有机磷和氧磷类似物对胆碱酯酶的抑制作用。列表数据表明，比色法足以确定工人是否接触了危险剂量的杀虫剂。
