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肺癌三联治疗的结果(术前或术后放射性同位素远距离治疗及放射性胶体金Au-198)

[Results of tri-component treatment of lung cancer (pre- or postoperative radioisotope teletherapy and radioactive colloid gold Au-198)].

作者信息

Ias'kevich L S

出版信息

Sov Med. 1990(10):25-9.

PMID:1963502
Abstract

Radical surgery adjuvant to pre- or postoperative teleradiotherapy and intravenous injection of radioactive colloid gold did not aggravate the course of the postoperative period in pulmonary carcinoma patients, nor did it increase the total number of postoperative complications and the postoperative mortality. Side effects of treatment presenting as radiation responses were transitory and cured conservatively. Three-component treatment for pulmonary carcinoma, including preoperative irradiation in doses 20, 30 Gy, radical surgery, and intravenous 198Au after surgery is indicated to patients with Stage III pulmonary adenocarcinoma and epidermoid cancer, whose 5-year survival rate elevated by 36 and 30 percent, respectively, as against surgical treatment, and to those with stages II and III metastatic adenocarcinoma and epidermoid cancer of the lungs, whose 5-year survival rate increased by 39 and 32 percent, respectively, as against those treated surgically.

摘要

根治性手术辅助术前或术后远距离放疗以及静脉注射放射性胶体金,并未加重肺癌患者术后病程,也未增加术后并发症总数及术后死亡率。治疗中表现为放射反应的副作用是暂时的,可通过保守治疗治愈。对于Ⅲ期肺腺癌和肺鳞癌患者,以及Ⅱ期和Ⅲ期肺转移性腺癌和肺鳞癌患者,采用包括20、30戈瑞术前照射、根治性手术及术后静脉注射198Au的三联疗法。与手术治疗相比,前者5年生存率分别提高了36%和30%,后者5年生存率分别提高了39%和32%。

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