Xu Peng, Zhang Yuan-Yuan, Sun Yong-Xue, Liu Jian-Hua, Yang Bing, Wang Yu-Zhong, Wang Yu-Liang
College of Chemistry, Sichuan University, Chengdu, China.
Chem Biol Drug Des. 2009 Jun;73(6):655-60. doi: 10.1111/j.1747-0285.2009.00821.x.
Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.
合成了10种在侧链含有硫醚部分以及杂环甲酰胺或氯甲酸酯基团的新型截短侧耳素衍生物，并通过¹H NMR、IR和HRMS进行了确证。抗菌活性结果表明，标题化合物对金黄色葡萄球菌具有优异的抗菌活性，其中5f的最低抑菌浓度达到0.03125μg/mL。
