基于二苯甲酮的一系列新型类似物的设计、合成及抗真菌活性
Design, synthesis and antifungal activity of a series of novel analogs based on diphenyl ketones.
作者信息
Liu Wei, Shi Hui-Min, Jin Hong, Zhao Hao-Yu, Zhou Guo-Ping, Wen Fang, Yu Zhi-Yi, Hou Tai-Ping
机构信息
Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
出版信息
Chem Biol Drug Des. 2009 Jun;73(6):661-7. doi: 10.1111/j.1747-0285.2009.00820.x.
To find potent fungicides, 35 analogs of diphenyl ketones were synthesized and evaluated for their antifungal activity. These compounds possessed a furyl-carbonyl-phenyl skeleton. Bioassay results showed that the synthesized compounds were effective in promoting the antifungal activity of diphenyl ketones. Compound 3 showed the best activity against the four tested fungi (100%, 100%, 100% and 96.4%) and could be used as potent fungicide for further research.
为了寻找高效杀菌剂，合成了35种二苯甲酮类似物，并对其抗真菌活性进行了评估。这些化合物具有呋喃基-羰基-苯基骨架。生物测定结果表明，合成的化合物能有效提高二苯甲酮的抗真菌活性。化合物3对四种受试真菌表现出最佳活性（100%、100%、100%和96.4%），可作为高效杀菌剂用于进一步研究。
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