Yang Lei, Guo Zhu-Ming, Chen Wen-Kuan, Zeng Zong-Yuan
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P.R. China.
Ai Zheng. 2009 Jun;28(6):637-41.
Lymphatic microvessels may play an important role in tumor metastasis. This study detected lymphatic microvessel density (LVD) in supraglottic laryngeal carcinoma to find its correlation to clinicopathologic characteristics, and to assess its prognostic significance in supraglottic laryngeal carcinoma.
Clinical data of 51 supraglottic laryngeal carcinoma patients who underwent primary lesion resection were reviewed. Immunohistochemical staining was performed with podoplanin monoclonal antibody to recognize lymphatic microvessels. The correlations of LVD to clinicopathologic characteristics and prognosis were analyzed.
The mean LVD was 3.25+/-2.37, with a median of 3, in the 51 specimens of supraglottic laryngeal carcinoma. LVD was significantly higher in the patients with cervical lymph node metastasis than in those without (P=0.009). The overall 5-year survival rate was 54.9%. The 5-year survival rate was significantly lower in the patients with poorly differentiated tumor, stages T3-4 disease, lymph node metastasis, stages III-IV disease and high LVD than in their counterparts. Cox regression analysis revealed that LVD, T classification, and differentiation were independent factors for survival.
LVD is related to lymph nodes status, and is an independent factor for prognosis of supraglottic laryngeal carcinoma.
淋巴管微血管可能在肿瘤转移中发挥重要作用。本研究检测声门上型喉癌组织中的淋巴管微血管密度（LVD），以探讨其与临床病理特征的相关性，并评估其对声门上型喉癌预后的意义。
回顾性分析51例接受原发灶切除的声门上型喉癌患者的临床资料。采用血小板内皮细胞黏附分子单克隆抗体进行免疫组织化学染色识别淋巴管微血管。分析LVD与临床病理特征及预后的相关性。
51例声门上型喉癌标本的平均LVD为3.25±2.37，中位数为3。有颈部淋巴结转移患者的LVD显著高于无转移者（P = 0.009）。5年总生存率为54.9%。肿瘤低分化、T3 - 4期、有淋巴结转移、Ⅲ - Ⅳ期及LVD高的患者5年生存率显著低于相应患者。Cox回归分析显示，LVD、T分期及分化程度是生存的独立因素。
LVD与淋巴结状态相关，是声门上型喉癌预后的独立因素。
