Zhao Yuejiao, Ji Wenyue, Tai Xuhui
Department of Head and Neck, Liaoning Province Tumor Hospital, Shenyang, 110042, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Mar;21(6):259-61.
To investigate the rule of lymphatic formation and the relationship between lymphatic formation and clinical pathological factors in supraglottic carcinoma.
Immunohistochemistry method and automatic image analysis technique were applied to observe the lymphatic quantity and state in central carcinoma tissue, join tissue and normal larynx mucosa of supraglottic carcinoma. Analyze the rule and the correlation between lymphatic formation and T stage, differentiation, lymph metastasis.
The lumen-lymphatic formation was not seen in central carcinoma tissue. There are little lymphatic in normal larynx mucosa whereas many lymphatic formation in join area. The lymphatic density in join tissue is correlated with T stage, differentiation and lymph metastasis: T(1-2) lower than T(3-4) and the difference is significant (P<0.01); The difference between high and middle differentiation is insignificant (P=0.212); High-middle differentiation lower than low differentiation and the difference is significant; No lower than N+ and the difference is significant (P<0.01).
In join area, there are lymphatic formation both in carcinoma area and para-tumor area. Tumor cell can go to lymph nodes via this pathway. This conclusion provides theoretical basis for clinical utility of the anti-tumor medicines which inhibitable lymphatic formation. It can help surgeons forecast prognosis and select more effective treatment method to observe join lymphatic vessel quantity.
探讨声门上型癌淋巴管生成规律及其与临床病理因素的关系。
采用免疫组织化学方法及自动图像分析技术，观察声门上型癌中心癌组织、交界组织及正常喉黏膜的淋巴管数量及状态。分析淋巴管生成与T分期、分化程度、淋巴结转移的规律及相关性。
中心癌组织未见管腔型淋巴管生成。正常喉黏膜淋巴管较少，而交界区淋巴管生成较多。交界组织淋巴管密度与T分期、分化程度及淋巴结转移相关：T（1-2）期低于T（3-4）期，差异有统计学意义（P<0.01）；高分化与中分化之间差异无统计学意义（P=0.212）；高-中分化低于低分化，差异有统计学意义；不低于N+，差异有统计学意义（P<0.01）。
在交界区，癌区及癌旁区均有淋巴管生成。肿瘤细胞可通过此途径进入淋巴结。该结论为抑制淋巴管生成的抗肿瘤药物临床应用提供了理论依据。有助于外科医生预测预后，通过观察交界区淋巴管数量选择更有效的治疗方法。
