Widman Douglas G, Ishikawa Tomohiro, Winkelmann Evandro R, Infante Ernesto, Bourne Nigel, Mason Peter W
Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, United States.
Vaccine. 2009 Sep 18;27(41):5550-3. doi: 10.1016/j.vaccine.2009.07.016. Epub 2009 Jul 25.
West Nile virus (WNV) causes significant disease, yet no vaccines exist to prevent WN disease in humans. We have previously reported that RepliVAX WN is a safe and efficacious vaccine in mouse and hamster models of WN disease. Here, we report that vaccination of hamsters with RepliVAX WN induces antibody responses that remain stable for at least 6 months. Furthermore, animals challenged with virulent WNV 6 months after vaccination were protected from disease as well as those challenged 2 months post-vaccination, with no vaccinated animals succumbing to WNV challenge. These results indicate that RepliVAX is capable of inducing durable protective immunity after a single dose.
西尼罗河病毒（WNV）会引发严重疾病，但目前尚无预防人类西尼罗河疾病的疫苗。我们之前曾报道，RepliVAX WN在西尼罗河疾病的小鼠和仓鼠模型中是一种安全有效的疫苗。在此，我们报告，用RepliVAX WN对仓鼠进行疫苗接种可诱导至少持续6个月的稳定抗体反应。此外，接种疫苗6个月后受到强毒力WNV攻击的动物与接种疫苗2个月后受到攻击的动物一样受到疾病保护，没有接种疫苗的动物死于WNV攻击。这些结果表明，RepliVAX能够在单剂量接种后诱导持久的保护性免疫。
