Kocken Clemens H M, Zeeman Anne-Marie, Voorberg-van der Wel Annemarie, Thomas Alan W
Department of Parasitology, Biomedical Primate Research Centre, GH Rijswijk, The Netherlands.
Trends Parasitol. 2009 Aug;25(8):370-4. doi: 10.1016/j.pt.2009.05.009. Epub 2009 Jul 25.
Plasmodium knowlesi is a primate malaria parasite that is phylogenetically close to the major human parasite Plasmodium vivax. P. knowlesi causes life-threatening disease in humans, infects a wide range of non-human primates and is one of few malaria parasites amenable to cyclical in vitro propagation. A robust in vivo and in vitro genetic manipulation system has been developed for this parasite, enabling in vitro-in vivo shuttling of transgenes, which (together with recent characterization of its genome and that of its macaque experimental host) offers unique opportunities to gain insight in molecular function and parasite-host interactions.
诺氏疟原虫是一种灵长类疟原虫，在系统发育上与主要的人类疟原虫间日疟原虫相近。诺氏疟原虫可导致人类危及生命的疾病，感染多种非人灵长类动物，并且是少数适合在体外进行周期性繁殖的疟原虫之一。针对这种疟原虫已开发出强大的体内和体外基因操作体系，能够实现转基因在体外和体内的穿梭，这（连同其基因组及其猕猴实验宿主基因组的近期特征）为深入了解分子功能和寄生虫与宿主的相互作用提供了独特的机会。
