Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm SE-17176, Sweden.
Clin Immunol. 2010 Jan;134(1):33-46. doi: 10.1016/j.clim.2009.07.002. Epub 2009 Jul 26.
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity and T cells in particular regulate the magnitude of the atherogenic pro-inflammatory response. T cells also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. This review summarizes our current understanding of T cells in atherogenesis, including which antigens they recognize, the role of T cell costimulation/coinhibition, and their secretion of pro- and anti-inflammatory mediators. Furthermore, we outline future areas of research and potential clinical intervention strategies.
动脉粥样硬化涉及炎症性动脉病变的形成，是全球最常见的死亡原因之一。二十多年来，适应性免疫特别是 T 细胞调节动脉粥样硬化炎症反应的程度已经很明显。T 细胞也影响动脉粥样硬化病变的稳定性，从而影响血栓形成的倾向和疾病的临床结果。这篇综述总结了我们目前对 T 细胞在动脉粥样硬化形成中的认识，包括它们识别哪些抗原、T 细胞共刺激/共抑制的作用以及它们分泌的促炎和抗炎介质。此外，我们还概述了未来的研究领域和潜在的临床干预策略。
