Maisonneuve I M, Keller R W, Glick S D
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Brain Res. 1990 Dec 10;535(2):221-6. doi: 10.1016/0006-8993(90)91604-f.
The effects of behaviorally equivalent doses of D-amphetamine and cocaine on extracellular dopamine (DA) levels in the left and right medial prefrontal cortex (PFC) were investigated using microdialysis in anesthetized rats. The two drugs increased extracellular DA levels to a similar extent and, in each case, there was a tendency for the effects to be greater in the left than in the right side of the brain. For both drugs, there was a strong negative correlation between basal levels and the magnitude of the drug response; this relationship, while important to consider when comparing one drug to another, could not account for the left-right differences in drug effects. Contrary to some previous reports, the present data indicate that D-amphetamine and cocaine do not differ substantially with regard to their effects on dopamine neurotransmission in the PFC.
在麻醉大鼠中，使用微透析技术研究了行为等效剂量的D-苯丙胺和可卡因对左右内侧前额叶皮质（PFC）细胞外多巴胺（DA）水平的影响。这两种药物使细胞外DA水平升高的程度相似，并且在每种情况下，左侧大脑的效应往往比右侧更大。对于这两种药物，基础水平与药物反应幅度之间存在强烈的负相关；这种关系虽然在比较一种药物与另一种药物时很重要，但无法解释药物效应的左右差异。与之前的一些报道相反，目前的数据表明，D-苯丙胺和可卡因对PFC中多巴胺神经传递的影响没有实质性差异。
