Jaskiw G E, Karoum F, Freed W J, Phillips I, Kleinman J E, Weinberger D R
Clinical Brain Disorders Branch, National Institutes of Mental Health, St. Elizabeths Hospital, Washington, DC 20032.
Brain Res. 1990 Nov 26;534(1-2):263-72. doi: 10.1016/0006-8993(90)90138-2.
To determine the influence of intrinsic medial prefrontal cortex (MPFC) neurons on regional brain catecholamine turnover, dopamine (DA) and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the MPFC in the rat. The locomotor response to D-amphetamine was also assessed. On the 14th postoperative day levels of DA, homovanillic acid concentrations and 3,4-dihydroxyphenylacetic acid were elevated in the anterior striatum of IA-lesioned animals. Spontaneous and amphetamine-induced locomotion were also increased. These changes disappeared by the 28th postoperative day. It is concluded that destruction of the efferents of the MPFC induces transient increases in DA turnover within the medial striatum and transiently increases spontaneous and amphetamine-induced locomotion.
为了确定内侧前额叶皮质（MPFC）固有神经元对脑区儿茶酚胺周转率的影响，在大鼠MPFC双侧注射鹅膏蕈氨酸（IA）损伤后14天和28天，对几个脑区的多巴胺（DA）及其代谢产物进行了测定。还评估了对D-苯丙胺的运动反应。术后第14天，IA损伤动物的前纹状体中DA水平、高香草酸浓度和3,4-二羟基苯乙酸升高。自发运动和苯丙胺诱导的运动也增加。这些变化在术后第28天消失。得出的结论是，MPFC传出纤维的破坏会导致内侧纹状体内DA周转率短暂增加，并使自发运动和苯丙胺诱导的运动短暂增加。
