Sellyei Boglárka, Varga Zsuzsanna, Szentesi-Samu Katalin, Kaszanyitzky Eva, Magyar Tibor
Veterinary Medical Research Institute of the Hungarian Academy of Sciences, P.O. Box 18 H-1581 Budapest, Hungary.
Acta Vet Hung. 2009 Sep;57(3):357-67. doi: 10.1556/AVet.57.2009.3.2.
Pasteurella multocida causes infectious diseases in a wide range of animal species. Antimicrobial therapy is still an effective tool for treatment. Generally, P. multocida isolates are susceptible to most of the widely used commercial antimicrobial agents but their excessive and unjustified use accelerates the emergence of resistant strains. We defined the antimicrobial sensitivity pattern of 56 P. multocida strains isolated from poultry (20) and swine [16 P. multocida toxin (PMT) positive and 20 PMT negative] to 16 widely applied antibiotics (apramycin, cefquinome, chloramphenicol, colistin, doxycycline, enrofloxacin, erythromycin, florfenicol, flumequine, neomycin, oxolinic acid, penicillin, trimethoprim potentiated sulphamethoxazole, sulphonamide compounds, tetracycline, tulathromycin) by the disk diffusion method. The majority of the strains was susceptible to most of the antimicrobial agents tested. However, the resistance to sulphonamides, tetracyclines, first-generation quinolones and aminoglycosides was remarkable, and thus the use of these compounds for the treatment of infection caused by P. multocida is not recommended. On the other hand, the antimicrobial activity of the classical penicillin, the newer macrolide (tulathromycin), the third-generation fluoroquinolone (enrofloxacin) and the fourth-generation cephalosporin (cefquinome) proved to be satisfactory against this bacterium.
多杀性巴氏杆菌可在多种动物物种中引发传染病。抗菌治疗仍是一种有效的治疗手段。一般来说，多杀性巴氏杆菌分离株对大多数广泛使用的商用抗菌药物敏感，但这些药物的过度和不合理使用加速了耐药菌株的出现。我们采用纸片扩散法，确定了从家禽（20株）和猪（16株多杀性巴氏杆菌毒素（PMT）阳性和20株PMT阴性）中分离出的56株多杀性巴氏杆菌对16种广泛应用的抗生素（阿普拉霉素、头孢喹肟、氯霉素、黏菌素、强力霉素、恩诺沙星、红霉素、氟苯尼考、氟甲喹、新霉素、恶喹酸、青霉素、甲氧苄啶增效磺胺甲恶唑、磺胺类化合物、四环素、泰拉霉素）的抗菌敏感性模式。大多数菌株对所测试的大多数抗菌药物敏感。然而，对磺胺类、四环素类、第一代喹诺酮类和氨基糖苷类的耐药性较为显著，因此不建议使用这些化合物来治疗由多杀性巴氏杆菌引起的感染。另一方面，经典青霉素、新型大环内酯类（泰拉霉素）、第三代氟喹诺酮类（恩诺沙星）和第四代头孢菌素（头孢喹肟）对这种细菌的抗菌活性被证明是令人满意的。
