Bengzon J, Kalén P, Lindvall O
Department of Medical Cell Research, University of Lund, Sweden.
Brain Res. 1990 Dec 10;535(2):353-7. doi: 10.1016/0006-8993(90)91624-p.
The in vivo microdialysis technique was used to monitor steady-state noradrenaline release in the rat hippocampus after hippocampal kindling. At 8 weeks after the last seizure, the noradrenaline release was reduced by 62% in the stimulated hippocampus in kindled animals as compared to non-kindled rats. The reduction was not due to the repeated handling of the animals as assessed in a separate experiment. The results suggest a decrease of inhibitory noradrenergic influence at the primary kindling site, which could play a role in kindling epileptogenesis.
采用体内微透析技术监测海马点燃大鼠海马中去甲肾上腺素的稳态释放。在末次发作8周后，与未点燃大鼠相比，点燃动物受刺激海马中的去甲肾上腺素释放减少了62%。在一项单独实验中评估发现，这种减少并非由于对动物的反复处理所致。结果表明，在原发性点燃部位，抑制性去甲肾上腺素能影响减弱，这可能在点燃癫痫发生过程中起作用。
