去甲肾上腺素能和血清素能系统在海马点燃效应中的作用。

The role of noradrenergic and serotonergic systems in the hippocampal kindling effect.

作者信息

Araki H, Aihara H, Watanabe S, Ohta H, Yamamoto T, Ueki S

出版信息

Jpn J Pharmacol. 1983 Feb;33(1):57-64. doi: 10.1254/jjp.33.57.

DOI:10.1254/jjp.33.57

Abstract

The role of the noradrenergic and the serotonergic systems in the development of hippocampal and amygdaloid kindling was studied. Dorsal noradrenaline bundle lesions markedly facilitated the formation of hippocampal and amygdaloid kindling. The most significant facilitation was observed in the earliest phase of kindling. Cortical noradrenaline content decreased by about 70% after dorsal noradrenaline bundle lesions. Midbrain raphe nuclei (both dorsal and medial raphe nuclei) lesions did not have any effect on the formation of both hippocampal and amygdaloid kindling. These results indicate that the dorsal noradrenaline bundle system plays an inhibitory role in the development of the seizure discharges and the behavioral convulsions in hippocampal and amygdaloid kindling.

摘要

研究了去甲肾上腺素能和5-羟色胺能系统在海马和杏仁核点燃形成过程中的作用。去甲肾上腺素背束损伤显著促进了海马和杏仁核点燃的形成。在点燃的最早阶段观察到最显著的促进作用。去甲肾上腺素背束损伤后，皮质去甲肾上腺素含量下降约70%。中脑缝核（背侧和中缝核）损伤对海马和杏仁核点燃的形成均无任何影响。这些结果表明，去甲肾上腺素背束系统在海马和杏仁核点燃的癫痫放电和行为惊厥的发展中起抑制作用。