Timing the Phox-trot: duration of Phox2a-dependent transcription is controlled by an intramolecular dephosphorylation/phosphorylation clock.
作者信息
Eiden Lee E
机构信息
Section on Molecular Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892-4090, USA.
出版信息
Mol Cell Biol. 2009 Sep;29(18):4875-7. doi: 10.1128/MCB.00972-09. Epub 2009 Jul 27.
Abstract
摘要
相似文献
1
Timing the Phox-trot: duration of Phox2a-dependent transcription is controlled by an intramolecular dephosphorylation/phosphorylation clock.把握狐步舞节奏：Phox2a 依赖性转录的持续时间由分子内去磷酸化/磷酸化时钟控制。
Mol Cell Biol. 2009 Sep;29(18):4875-7. doi: 10.1128/MCB.00972-09. Epub 2009 Jul 27.
2
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription.环磷酸腺苷（cAMP）途径对Phox2a的时间依赖性激活调节了p27Kip1转录的起始和持续时间。
Mol Cell Biol. 2009 Sep;29(18):4878-90. doi: 10.1128/MCB.01928-08. Epub 2009 Jun 29.
3
Homeodomain transcription factor Phox2a, via cyclic AMP-mediated activation, induces p27Kip1 transcription, coordinating neural progenitor cell cycle exit and differentiation.同源结构域转录因子Phox2a通过环磷酸腺苷介导的激活作用，诱导p27Kip1转录，从而协调神经祖细胞退出细胞周期并进行分化。
Mol Cell Biol. 2006 Dec;26(23):8826-39. doi: 10.1128/MCB.00575-06. Epub 2006 Sep 18.
4
The cAMP pathway regulates both transcription and activity of the paired homeobox transcription factor Phox2a required for development of neural crest-derived and central nervous system-derived catecholaminergic neurons.环磷酸腺苷（cAMP）信号通路调节配对型同源框转录因子Phox2a的转录和活性，而Phox2a是神经嵴衍生和中枢神经系统衍生的儿茶酚胺能神经元发育所必需的。
J Biol Chem. 2005 Dec 9;280(49):41025-36. doi: 10.1074/jbc.M503537200. Epub 2005 Oct 4.
5
The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status.配对样同源结构域蛋白Arix通过其磷酸化状态介导蛋白激酶A刺激的多巴胺β-羟化酶基因转录。
J Biol Chem. 2002 Jun 21;277(25):22915-24. doi: 10.1074/jbc.M201695200. Epub 2002 Apr 9.
6
[Expression and significance of Ser10 phosphorylated p27(kip1) and JAB1 protein in human hepatocellular carcinoma].[Ser10磷酸化p27（kip1）和JAB1蛋白在人肝细胞癌中的表达及意义]
Zhonghua Bing Li Xue Za Zhi. 2007 Dec;36(12):840-1.
7
The cAMP pathway in combination with BMP2 regulates Phox2a transcription via cAMP response element binding sites.环磷酸腺苷（cAMP）信号通路与骨形态发生蛋白2（BMP2）协同作用，通过环磷酸腺苷反应元件结合位点调控Phox2a转录。
J Biol Chem. 2006 Feb 3;281(5):2969-81. doi: 10.1074/jbc.M503939200. Epub 2005 Dec 5.
8
Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.细胞周期蛋白D3结合的CDK4的环磷酸腺苷依赖性磷酸化决定了甲状腺上皮细胞通过细胞周期限制点。
J Biol Chem. 2003 Jul 18;278(29):26533-40. doi: 10.1074/jbc.M302492200. Epub 2003 Apr 30.
9
Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene.成对样同源结构域蛋白Phox2a和Phox2b负责多巴胺β-羟化酶基因的去甲肾上腺素能细胞特异性转录。
J Neurochem. 1998 Nov;71(5):1813-26. doi: 10.1046/j.1471-4159.1998.71051813.x.
10
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.p27Kip1蛋白丝氨酸10位点和苏氨酸187位点的磷酸化位点突变消除了细胞质重新分布，但并未消除HepG2细胞系中的G0/1期阻滞。
Biochem Biophys Res Commun. 2006 Sep 1;347(3):601-7. doi: 10.1016/j.bbrc.2006.06.114. Epub 2006 Jun 28.
本文引用的文献
1
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription.环磷酸腺苷（cAMP）途径对Phox2a的时间依赖性激活调节了p27Kip1转录的起始和持续时间。
Mol Cell Biol. 2009 Sep;29(18):4878-90. doi: 10.1128/MCB.01928-08. Epub 2009 Jun 29.
2
A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells.一条依赖环磷酸腺苷（cAMP）、独立于蛋白激酶A的信号通路，通过早期生长反应蛋白1（Egr1）介导PC12细胞中的神经突生成。
Mol Pharmacol. 2008 Jun;73(6):1688-708. doi: 10.1124/mol.107.044792. Epub 2008 Mar 24.
3
Regulation of PC12 cell differentiation by cAMP signaling to ERK independent of PKA: do all the connections add up?通过cAMP信号传导至不依赖PKA的ERK对PC12细胞分化的调控：所有联系都合理吗？
Sci STKE. 2007 Apr 17;2007(382):pe15. doi: 10.1126/stke.3822007pe15.
4
Homeodomain transcription factor Phox2a, via cyclic AMP-mediated activation, induces p27Kip1 transcription, coordinating neural progenitor cell cycle exit and differentiation.同源结构域转录因子Phox2a通过环磷酸腺苷介导的激活作用，诱导p27Kip1转录，从而协调神经祖细胞退出细胞周期并进行分化。
Mol Cell Biol. 2006 Dec;26(23):8826-39. doi: 10.1128/MCB.00575-06. Epub 2006 Sep 18.
5
MAPK signal specificity: the right place at the right time.丝裂原活化蛋白激酶信号特异性：在正确的时间处于正确的位置。
Trends Biochem Sci. 2006 May;31(5):268-75. doi: 10.1016/j.tibs.2006.03.009. Epub 2006 Apr 17.
6
The cAMP pathway regulates both transcription and activity of the paired homeobox transcription factor Phox2a required for development of neural crest-derived and central nervous system-derived catecholaminergic neurons.环磷酸腺苷（cAMP）信号通路调节配对型同源框转录因子Phox2a的转录和活性，而Phox2a是神经嵴衍生和中枢神经系统衍生的儿茶酚胺能神经元发育所必需的。
J Biol Chem. 2005 Dec 9;280(49):41025-36. doi: 10.1074/jbc.M503537200. Epub 2005 Oct 4.
7
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.定义CREB调控子：转录因子调控区域的全基因组分析。
Cell. 2004 Dec 29;119(7):1041-54. doi: 10.1016/j.cell.2004.10.032.
8
Specification of catecholaminergic and serotonergic neurons.儿茶酚胺能和5-羟色胺能神经元的特化
Nat Rev Neurosci. 2002 Jul;3(7):531-41. doi: 10.1038/nrn871.
9
Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells.环磷酸腺苷信号在培养的原代神经嵴细胞的交感肾上腺细胞发育中起双模态开关的作用。
Mol Cell Biol. 2000 May;20(9):3004-14. doi: 10.1128/MCB.20.9.3004-3014.2000.
10
Transcriptional control of neurotransmitter phenotype.神经递质表型的转录调控。
Curr Opin Neurobiol. 1999 Feb;9(1):47-53. doi: 10.1016/s0959-4388(99)80006-3.
Zotero 插件