Andrade Marcia C R, Dick Edward J, Guardado-Mendoza Rodolfo, Hohmann Michaelle L, Mejido Diana C P, VandeBerg John L, DiCarlo Cheryl D, Hubbard Gene B
Department of Primatology, Center for Laboratory Animal Breeding, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Am J Trop Med Hyg. 2009 Aug;81(2):235-9.
Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.
在克氏锥虫的地方流行范围内，经常在狒狒中观察到非特异性淋巴细胞性心肌炎（NLM）。我们试图确定克氏锥虫感染是否是狒狒NLM的一个病因。我们评估了31只患有NLM的狒狒的心肌连续组织切片、血培养、免疫组织化学、血清学、聚合酶链反应和临床病理学，以确定克氏锥虫感染是否与NLM相关。11只无克氏锥虫血清学感染证据且无NLM的狒狒用作对照。患有NLM的狒狒中克氏锥虫血清阳性率为45%，而菌落流行率为2 - 3%。血清阳性的患有NLM的狒狒的NLM病变严重程度显著高于血清阴性的狒狒。NLM在老年狒狒中明显更常见。未发现NLM与性别、体重或临床病理学之间存在统计学关联。这些结果表明狒狒的NLM与克氏锥虫感染之间存在关联。
