Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
Am J Ther. 2010 Sep-Oct;17(5):e163-6. doi: 10.1097/MJT.0b013e3181b0a713.
Henoch-Schonlein purpura (HSP) is an acute leukocytoclastic vasculitis that primarily affects children but also affects approximately 1% of adults. We discuss a case of HSP that started after pantoprazole ingestion. Clinical manifestation included terminal ileitis and rapidly progressing glomerulonephritis. To our knowledge, this is the first reported case of HSP secondary to pantoprazole ingestion. The patient presented with renal failure requiring hemodialysis and was initially unresponsive to intravenous pulse steroids. The patient was treated with mycophenolate mofetil, and his renal function recovered. There are limited data regarding use of mycophenolate mofetil for treating crescentic glomerulonephritis secondary to HSP.
过敏性紫癜（HSP）是一种急性白细胞碎裂性血管炎，主要影响儿童，但也影响约 1%的成年人。我们讨论了一例在泮托拉唑摄入后发生的 HSP 病例。临床表现包括末端回肠炎和快速进展性肾小球肾炎。据我们所知，这是首例报道的泮托拉唑摄入引起的 HSP 病例。该患者表现为肾衰竭，需要血液透析，并且最初对静脉注射脉冲类固醇无反应。该患者接受吗替麦考酚酯治疗，其肾功能恢复。关于用吗替麦考酚酯治疗 HSP 引起的新月体性肾小球肾炎的数据有限。
