Fukai K, Ishii M, Kobayashi H, Chanoki M, Furukawa M, Nakagawa K, Hamada T, Abe Y, Ooshima A
Department of Dermatology Osaka City University Medical School, Japan.
J Cutan Pathol. 1990 Dec;17(6):374-80. doi: 10.1111/j.1600-0560.1990.tb00115.x.
A primary adenoid cystic carcinoma of the skin is reported. Light microscopy revealed pseudocysts. PAS-positive basement membrane and true glandular lumen, which in aggregates are specific for adenoid cystic carcinoma. Perineural invasion was also observed. Ultrastructural examinations revealed three types of cystic spaces; pseudocysts, true glandular lumens and intercellular spaces. Enzyme histochemical examinations showed positive reactions for eccrine enzymes, including phosphorylase and succinic dehydrogenase and negative for apocrine enzymes. Immunolocalization of collagens and laminin revealed that basement membranes of the pseudocysts involve Type V collagen as well as Type IV collagen and laminin.
报告了一例原发性皮肤腺样囊性癌。光镜检查发现假囊肿。PAS阳性的基底膜和真正的腺腔，其聚集状态是腺样囊性癌的特征性表现。还观察到神经周围浸润。超微结构检查显示有三种类型的囊腔；假囊肿、真正的腺腔和细胞间隙。酶组织化学检查显示，外分泌酶（包括磷酸化酶和琥珀酸脱氢酶）呈阳性反应，而顶泌酶呈阴性反应。胶原蛋白和层粘连蛋白的免疫定位显示，假囊肿的基底膜涉及V型胶原蛋白以及IV型胶原蛋白和层粘连蛋白。
