Hedgepeth Ryan C, Zhou Ming, Ross Jonathan
Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA.
J Pediatr Hematol Oncol. 2009 Aug;31(8):602-4. doi: 10.1097/MPH.0b013e3181acd981.
We report the case of a 5-year-old girl with metastatic renal cell carcinoma (RCC) diagnosed 19 months after treatment for neuroblastoma. Immunostaining of the secondary tumor was consistent with Xp11 translocation morphology. This is the second report of this translocation RCC presenting after neuroblastoma and the most rapid onset of RCC reported thus far. The literature regarding secondary RCC after neuroblastoma is reviewed and our case is placed within this historical context. As our understanding of the genetic changes in pediatric tumors advances, the reporting of these rare cases with specific emphasis on genetic testing provides a resource for clinicians and researchers.
我们报告了一名5岁女孩的病例，她在接受神经母细胞瘤治疗19个月后被诊断为转移性肾细胞癌（RCC）。继发肿瘤的免疫染色与Xp11易位形态一致。这是第二例神经母细胞瘤后出现的这种易位性肾细胞癌报告，也是迄今为止报告的肾细胞癌发病最快的病例。本文回顾了关于神经母细胞瘤后继发性肾细胞癌的文献，并将我们的病例置于这一历史背景中。随着我们对儿童肿瘤基因变化的理解不断深入，对这些罕见病例进行报告并特别强调基因检测，可为临床医生和研究人员提供参考资源。
